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Your Vote Counts! AKOUOS, INC. Important Notice Regarding the Availability of Proxy Materials for the Shareholder Meeting to Be Held on June 24, 2021 2021 Annual Meeting June 24, 2021 9:00 AM EDT Virtual Meeting Site: www.virtualshareholdermeeting.com/AKUS2021 AKOUOS, INC. 645 SUMMER ST. SUITE 200 BOSTON, MA 02210 D50310-P49419 You invested in AKOUOS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to June 10, 2021. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Smartphone users Point your camera here and vote without entering a control number Vote In Advance of the Meeting Vote by June 23, 2021 11:59 PM ET. Visit www.ProxyVote.com. Vote Virtually at the Meeting* Vote on June 24, 2021 9:00 a.m. Eastern Time Visit www.virtualshareholdermeeting.com/AKUS2021 *Please check the meeting materials for any special requirements for meeting attendance. V1 To view the proxy materials and to vote, visit www.ProxyVote.com Control #

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Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items D50311-P49419 Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. 1. Election of Class I Directors Nominees: 01) Kush M. Parmar 02) Emmanuel Simons 03) Chris Smith For 2. Ratify the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2021. For NOTE: Such other business as may properly come before the meeting or any adjournment thereof.